Topoisomerase II is critical for DNA replication. transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins. However. these drugs are limited by common tumor resistance mechanisms and side-effect profiles. https://www.spidertattooz.com/The-GelBottle-Inc-Gel-Polish-Cashmere-67oz-p20053/