The conclusion that MMPs mediate the breaking down of type II collagen and that aggrecan is wrecked by relevant metalloproteinases called adamalysins with thrombospondin motifs (ADAMTSs) is supported by a substantial entire body of proof [ten]. Hyaluronic acid is usually a naturally occurring element of joint cartilage matrix and synovial fluid. https://www.theorthopaedicandpainpractice.com/all-you-need-to-know-about-osteoarthritis/